A. he liked his office work                 B. he was satisfied with the pay

C. his employer provided health insurance       D. he hated gaps between contracts

45. What does the word“trade-offs”in Paragraph five mean？

A. Benefits         B. Compromises      C. Risks                D. Disadvantages

Passage Four

Scientists are hoping to eliminate malaria（疟疾）by developing a genetically modified mosquito that cannot transmit the disease. Malaria has long troubled the populations of South America，Africa，and Asia，where mosquito bites infect up to 500 million people a year with this serious and sometimes fatal parasitic blood disease. For generations，scientists have been trying to eliminate malaria by developing new drugs and using pesticide（杀虫剂）to wipe out local mosquito populations. But these measures aren’t working—and some scientists，like Greg Lanzaro，say that because of drug resistance and population changes，malaria is actually more prevalent now than it was 20 years ago. Lanzaro says he has a better way to stop the spread of malaria：genetically modifying mosquitoes so they are unable to carry the disease.

Lanzaro and his colleagues are planning a multi-year project to produce malaria-resistant mosquitoes—and he thinks they can do it within five years.“We can get foreign genes into mosquitoes and they go where they’re supposed to go，”Lanzaro says，pointing out that scientists have already succeeded in genetically engineering mosquitoes that cannot transmit malaria to birds and mice. And，he says，scientists are quickly making progress on genes that block transmission of the disease to humans as well.

The most difficult part scientifically，Lanzaro says，is figuring out how to get the lab-engineered mosquitoes to spread their genes into natural populations after all，he points out，it’s useless to engineer mosquitoes in the lab that can’t transmit malaria when there are millions out in the wild that can. To solve this problem，Lanzaro wants to load up a mobile piece of DNA with the malaria-resistant gene，and then insert it into a group of mosquito embryos. The malaria-resistant gene would be integrated directly into the mosquitoes’ DNA，making it impossible for those mosquitoes to transmit the parasite that causes malaria. In this way a small group of lab-raised mosquitoes could be released into the wild，and by interbreeding with wild mosquitoes，eventually transmit the beneficial gene to the entire population.

46. One reason for malaria to be more widespread now is that         .