导师姓名：李恭楚
性别：男
人气指数：343

所属院校：浙江理工大学
所属院系：生命科学学院
职称：副教授
导师类型：
招生专业：生物学
研究领域： 1.凝集素基因在癌症基因治疗中的应用及机制研究2.溶瘤腺病毒及痘苗病毒的分子靶向改造
研究领域： 1.凝集素基因在癌症基因治疗中的应用及机制研究2.溶瘤腺病毒及痘苗病毒的分子靶向改造 [收起]




通讯方式 :
办公电话：**
通讯地址：浙江杭州下沙浙江理工大学生命科学学院


个人简述 :
主要学习工作经历

1.纽约州立大学宾汉姆顿分校生物科学系博士

2.华东师范大学生物学系 学士、硕士
科研教学项目

主持的项目：

1.国家自然科学基金面上项目，“凝集素基因在溶瘤痘苗病毒为载体的癌症基因治疗中的应用及分子机制研究”（**）2016.01-2019.12

2.浙江省自然科学基金重点项目，“海洋凝集素基因在肿瘤基因治疗中的应用及作用机制研究”（LZ16D060002）2016.01-2019.12

3.国家自然科学基金青年项目，“通过急性髓性白血病干细胞表面CD123导入溶瘤腺病毒的实验研究” （**）2009.01-2011.12

4. 医学转化项目（横向）“溶瘤病毒对肿瘤及乙型肝炎的影响研究”
作为实际负责人的项目：

1.国家自然科学基金青年项目，“掌叶半夏凝集素细胞内表达杀伤肺癌细胞的研究”（**）2009.01-2011.12
学术兼职

1.法国国家科研署(French National Research Agency, ANR)基金项目评审专家

2.Drug Delivery、Oncotarget、Glycoconjugate J、Cell Biol Toxicol等国际期刊审稿人


科研工作 :
Selected Publications （§：第一作者；*：通讯作者）

☆ G Li*, Z Zhao, B Wu, Q Su, L Wu, X Yang, J Chen. Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells. Glycoconjugate Journal 34: 489-498. 2017

☆ B Wu, S Mei, L Cui, Z Zhao, J Chen, T Wu, G Li*. Marine lectins DlFBL and HddSBL fused with coxsackie-adenovirus receptor facilitate adenovirus infection in cancer cells but have different effects on cell survival. Marine Drugs 15: 73. 2017

☆ G Li*, Y Gao, L Cui, L Wu, X Yang, J Chen*. Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5. The Journal of Gene Medicine 18: 65-74. 2016

☆ G Li*, H Wu, L Cui, Y Gao, L Chen, X Li, T Liang, X Yang, J Cheng, J Luo. CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth. Oncotarget6: 43496-43507. 2015

☆ L Wu§, X Yang§, X Duan, L Cui, G Li*. Exogenous expression of marine lectins DlFBL and SpRBL induces cancer cell apoptosis possibly through PRMT5-E2F-1 pathway. Scientific Reports 4: 4505. 2014

☆ G Li*, X Li, H Wu, X Yang, Y Zhang, L Chen, X Wu, L Cui, L Wu, J Luo, XY Liu. CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo. Blood Cancer Journal 4: e194. 2014

☆ X Yang§, L Wu§, X Duan, L Cui, J Luo, G Li*. Adenovirus carrying gene encoding Haliotis discus discus sialic acid binding lectin induces cancer cell apoptosis. Marine Drugs 12: 3994-4004. 2014

☆ N Li§, G Dong§, S Wang, S Zhu, Y Shen, G Li*. Pinellia pedatisecta agglutinin-based lectin blot analysis distinguishes between glycosylation patterns in various cancer cell lines. Oncology Letters 8: 837-840. 2014

☆ K Chen, X Yang, L Wu, M Yu, X Li, N Li, S Wang, G Li*. Pinellia pedatisecta agglutinin targets drug resistant K562/ADR leukemia cells through binding with sarcolemmal membrane associated protein and enhancing macrophage phagocytosis. PLoS ONE 8: e74363. 2013

☆ Q Lu§, N Li§, J Luo, M Yu, Y Huang, X Wu, H Wu, XY Liu, G Li*. Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death. Oncogenesis 1: e29. 2012

☆ BJ Rafferty§, G Li§, DW McGee*. Activation of the α3 integrin affects TRAF6 function in the IL-1 signaling pathway of Caco-2 epithelial cells. Immunological Investigations 39: 1-15. 2010

☆ GC Li§, N Li§, YH Zhang, X Li, YG Wang, XY Liu, WB Qian*, XC Liu*. Mannose-exposing myeloid leukemia cells detected by the sCAR-PPA fusion protein. International Journal of Hematology 89: 611-617. 2009

☆ G Li, FD Lubin, DW McGee*. α3β1 integrin induced Suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-κB activation. Cellular Immunology 231: 30-39. 2004